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arylsulfatase-C (steryl-3-sulfatase, steroid sulfatase, ASC, STS ARSC1)
Function:
- hydrolyzes 3-beta-hydroxy steroid sulfates
- conversion of sulfated steroid precursors to estrogens during pregnancy
Cofactor: binds 1 Ca+2 per subunit
Structure:
- homodimer belongs to the sulfatase family
Compartment: endoplasmic reticulum membrane
Pathology:
- defects in STS are the cause of X-linked ichthyosis
General
arylsulfatase
glycoprotein
membrane protein
Properties
SIZE: entity length = 583 aa
MW = 65 kD
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: exoplasmic domain {1-184}
MOTIF: signal sequence {1-21}
Ca+2-binding site
SITE: 35-35
Ca+2-binding site
SITE: 36-36
N-glycosylation site {N47}
Ca+2-binding site
SITE: 75-75
histidine residue {H136}
cysteine residue {C141}
MODIFICATION: cysteine residue {C148}
cysteine residue {C148}
MODIFICATION: cysteine residue {C141}
cysteine residue {C170}
MODIFICATION: cysteine residue {C242}
transmembrane domain {185-208}
cytoplasmic loop {209-212}
transmembrane domain {213-234}
exoplasmic domain {235-583}
MOTIF: cysteine residue {C242}
MODIFICATION: cysteine residue {C170}
N-glycosylation site {N259}
Not glycosylated {333-333}
Ca+2-binding site
SITE: 342-342
Ca+2-binding site
SITE: 343-343
cysteine residue {C446}
MODIFICATION: cysteine residue {C489}
Not glycosylated {459-459}
cysteine residue {C481}
MODIFICATION: cysteine residue {C487}
cysteine residue {C487}
MODIFICATION: cysteine residue {C481}
cysteine residue {C489}
MODIFICATION: cysteine residue {C446}
cysteine residue {C562}
MODIFICATION: cysteine residue {C570}
cysteine residue {C563}
MODIFICATION: cysteine residue {C572}
cysteine residue {C570}
MODIFICATION: cysteine residue {C562}
cysteine residue {C572}
MODIFICATION: cysteine residue {C563}
Database Correlations
OMIM 308100
UniProt P08842
Pfam PF00884
Entrez Gene 413
Kegg hsa:412
ENZYME 3.1.6.2
References
- OMIM :accession 301780
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=STS
- Wikipedia, steroid sulfatase entry
http://en.wikipedia.org/wiki/steroid_sulfatase
- UniProt :accession P08842