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arylamine N-acetyltransferase, polymorphic; arylamine N-acetyltransferase-2 (NAT2, AAC2, PNAT)
Function:
- role in the detoxification of a plethora of hydrazine & arylamine drugs
- catalyzes the N- or O-acetylation of various arylamine & heterocyclic amine substrates & is able to bioactivate several known carcinogens
acetyl-CoA + an arylamine CoA + an N-acetylarylamine
Structure: belongs to the arylamine N-acetyltransferase family
Compartment: cytoplasm
Pathology:
- N-acetylation polymorphism is determined by a low or high NAT activity in liver, it has been implicated in the action & toxicity of amine-containing drugs, & in the susceptibility to bladder cancer & systemic lupus erythematosus
General
arylamine N-acetyltransferase (NAT)
Properties
SIZE: entity length = 290 aa
MW = 34 kD
COMPARTMENT: cytoplasm
MOTIF: cysteine residue {C68}
histidine residue {H107}
aspartate residue {D122}
Tyr phosphorylation site {Y246}
Database Correlations
OMIM 243400
UniProt P11245
Pfam PF00797
Entrez Gene 10
Kegg hsa:10
ENZYME 2.3.1.5
References
- UniProt :accession P11245
- NAT; Note: NAT alleles
http://www.louisville.edu/medschool/pharmacology/NAT.html
- SHMPD;The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT2