arteriosclerosis

Hardening of the arteries. During normal aging 1) gradual accumulation of intimal smooth muscle surrounded by connective tissue 2) accumulation of sphingomyelin & cholesterol linoleate 3) slow, continuous, symmetric increase in thickness of intima Classification: 1) atherosclerosis 2) Monckenberg's arteriosclerosis 3) arteriolosclerosis Etiology: disorders associated with early arteriosclerosis 1) atherosclerosis a) diabetes mellitus b) hypertension c) familial hypercholesterolemia d) familial combined hyperlipidemia e) familial dysbetalipoproteinemia f) familial hypoalphalipoproteinemia g) hypothyroidism h) cholesterol ester storage disease i) systemic lupus erythematosus j) hyperhomocysteinemia 2) non-atheromatous arteriosclerosis a) diabetes mellitus b) chronic renal insufficiency c) chronic vitamin D intoxication d) pseudoxanthoma elasticum e) idiopathic arterial calcification in infancy f) aortic valvular calcification in the elderly g) Werner's syndrome

Specific

aortic valvular calcification atherosclerosis atherosclerotic intracranial arterial stenosis Monckenberg's arteriosclerosis

General

arterial occlusive disease chronic vascular disease (chronic vasculopathy)

References

Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995