Search
artemisinin
Indications:
- treatment of Plasmodium falciparum & Plasmodium vivax malaria
- may be useful for treating polycystic ovarian syndrome [4]
* use as monotherapy discouraged as resistance is spreading [2] throughout Southeast Asia
* artemisinin-resistant malaria found in Africa [3]
Mechanism of action:
- polycystic ovarian syndrome:
- artemisinin degrades LONP1-CYP11A,1 an enzyme essential for ovarian production of androgens (investigational) [4]
Interactions
drug adverse effects of antimalarials
Specific
dihydroartemisinin
General
antimalarial
heterocyclic compound, 4 or more rings
sesquiterpene
lactone
Database Correlations
PUBCHEM correlations
References
- Wikipedia:
http://en.wikipedia.org/wiki/Artemisinin
- Ashley EA et al.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
N Engl J Med 2014 Jul 31; 371:411
PMID: 25075834
http://www.nejm.org/doi/full/10.1056/NEJMoa1314981
- Balikagala B, Fukuda N, Ikeda M et al
Evidence of Artemisinin-Resistant Malaria in Africa.
N Engl J Med 2021; 385:1163-1171
PMID: 34551228
https://www.nejm.org/doi/10.1056/NEJMoa2101746
- Liu Y, Jiang JJ, Du SY et al
Artemisinins ameliorate polycystic ovarian syndrome by mediating
LONP1-CYP11A1 interaction.
Science. 2024 Jun 14;384(6701):eadk5382
PMID: 38870290
https://www.science.org/doi/10.1126/science.adk5382