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artemether/lumefantrine (Coartem)
FDA approved April 2009
Indications:
- treatment of acute, uncomplicated malaria in adults & children > 5 kg (11 lbs)
- treatment of Plasmodium falciparum [3]
Dosage:
- BID dosing for 3 days
- 5 - <15 kg: 1 tablet per dose
- 15 - <25 kg: 2 tablets per dose
- 25 - <35 kg: 3 tablets per dose
- >35 kg: 4 tablets per dose
- take with food, particularly food that contains fat
Tablet: 20mg artemether & 120 mg lumefantrine
Adverse effects:
- adults
- headache
- anorexia
- dizziness
- physical weakness (asthenia)
- arthralgia
- myalgia
- children
- fever (pyrexia)
- cough
- vomiting
- loss of appetite
- headache
Interactions
drug adverse effects of antimalarials
General
antibiotic combination
antimalarial
References
- FDA News
FDA Approves Coartem Tablets to Treat Malaria
http://www.fda.gov/bbs/topics/NEWS/2009/NEW01989.html
- Coartem, New Malaria Treatment Drug, Now Available
Centers for Disease Control and Prevention
http://www.cdc.gov/malaria/news/2009_05_coartem.htm
- Deprecated Reference
Components
artemether
lumefantrine