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beta-arrestin-2; arrestin beta-2 (ARRB2 ARB2 ARR2)
Function:
- regulates beta-adrenergic receptor function
- beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins
- binds to phosphorylated C-terminus of TGF-beta receptor 3, promotes endocytosis of TGFBR3 & downregulates TGF-beta signaling [2]
- Frizzled 4 binding to protein kinase C phosphorylated dishevelled 2 recruits beta-arrestin 2; further stimulation by wnt5A is required for endocytosis via clathrin coated pits [1]
Structure: belongs to the arrestin family
Compartment: cytoplasm (putative), nucleus
Alternative splicing: named isoforms=3
Comparative biology:
- mice without functional beta-arrestin-2 are 3 times more sensitive to the analgesic effect of morphine than normal mice
- additionally the effects of morphine last 3 times as long
- these effects are mediated via the mu-opioid receptor (as they are nullified by naloxone)
General
beta-arrestin
phosphoprotein
Properties
SIZE: entity length = 409 aa
MW = 46 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Tyr phosphorylation site {Y48}
peptide motif {389-399}
Database Correlations
OMIM 107941
UniProt P32121
PFAM correlations
Entrez Gene 409
Kegg hsa:409
References
- Chen W et al
Dishevelled 2 recruits beta-arrestin 2 to mediate
Wnt5A-stimulated endocytosis of Frizzled 4.
Science 301:1391-4, 2003
PMID: 12958364
- Chen W et al
Beta-arrestin 2 mediates endocytosis of type III TGF-beta
receptor and down-regulation of its signaling.
Science 301:1394-7, 2003
PMID: 12958365
- Journal Watch 20(3):27, 2000
- Bohn LM et al
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Science 286:2495, 1999
PMID: 10617462
- Entrez Gene :accession 409