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cAMP-regulated phosphoprotein 21; ARPP-21; thymocyte cAMP-regulated phosphoprotein (ARPP21, TARPP)
Function:
- substrate for cAMP-dependent kinase
- isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons
- phosphorylation at Ser-56 favors interaction with CALM1
- isoform 1 is methylated by CARM1 in immature thymocytes
- interacts with CALM1 (putative)
Structure: contains 1 R3H domain
Compartment: cytoplasm
Alternative splicing: named isoforms=6
Expression:
- isoform 2 is expressed in brain
- expressed in neurons within striatum
- isoform 1 is present in immature thymocytes (at protein level)
Interactions
molecular events
Related
cyclic adenosine monophosphate; cyclic AMP (cAMP)
General
phosphoprotein
Properties
SIZE: entity length = 812 aa
MW = 89 kD
COMPARTMENT: cytoplasm
CELL: neuron
WITHIN: striatum
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
coiled coil {32-58}
MOTIF: Ser phosphorylation site {S56}
R3H {164-227}
Ser phosphorylation site {S280}
serine-rich region {338-423}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S383}
glutamine-rich region {506-754}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM 605488
UniProt Q9UBL0
Pfam PF01424
Entrez Gene 10777
References
- Hemmings HC & Greengard P
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in
dopamine-innervated brain regions. I. Purification and
characterization of the protein from bovine caudate nucleus.
J Neurosci 9:851 1989
PMID: 2538584
- Ouimet CC et al
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched
in dopamine-innervated brain regions. II.
Immunocytochemical localization in rat brain.
J Neruosci 9:865 1989
PMID: 2538585
- Williams KR et al
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched
in dopamine-innervated brain regions. I.
Amino acid sequence of ARPP-21B from bovine caudate nucleus.
J Neurosci 9:3631 1989
PMID: 2552036
- Kurihara T et al
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched
in dopamine-innervated brain regions. II.
Molecular cloning and nucleotide sequence.
J Neurosci 9:3638 1989
PMID: 2552037
- UniProt :accession Q9UBL0