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actin-related protein 2/3 (ARP2/3) complex
Function:
- involved in regulation of actin polymerization
- together with an activating nucleation-promoting factor (NPF), mediates the formation of branched actin networks
Structure:
- subunits include: ACTR2/ARP2, ACTR3/ARP3, (ARPC1A or ARPC1B), ARPC2, ARPC3, ARPC4, (ARPC5 or ARPC5L)
General
multisubunit protein
Properties
SUBUNITS: actin-related protein 2/3 complex subunit 1A
MOTIF: WD repeat {6-45}
WD repeat {50-89}
WD repeat {140-179}
WD repeat {202-241}
WD repeat {244-284}
WD repeat {322-365}
actin-related protein 2/3 complex subunit 1B
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {6-45}
WD repeat {50-89}
WD repeat {94-135}
WD repeat {140-179}
WD repeat {242-280}
Ser phosphorylation site {S310}
WD repeat {324-367}
actin-related protein 2/3 complex subunit 2
actin-related protein 2/3 complex subunit 3
MOTIF: Tyr phosphorylation site {Y47}
actin-related protein 2/3 complex subunit 4
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
actin-related protein 2/3 complex subunit 5
ARPC5LL
References
- UniProt :accession O15511
- UniProt :accession Q92747
- UniProt :accession O15143
- UniProt :accession O15509
- UniProt :accession O15145
- UniProt :accession O15144
- UniProt :accession P32391
Components
actin-related protein 2/3 complex subunit 1A; SOP2-like protein (ARPC1A, SOP2L)
actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kD subunit; p41-ARC (ARPC1B, ARC41)
actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kD subunit; p34-ARC (ARPC2, ARC34, PRO2446)
actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kD subunit; p21-ARC (ARPC3, ARC21)
actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kD subunit; p20-ARC (ARPC4, ARC20)
actin-related protein 2/3 complex subunit 5; Arp2/3 complex 16 kD subunit; p16-ARC (ARPC5, ARC16)