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cytochrome P450 19A1 (aromatase, estrogen synthetase, CYP19A1)
Function:
- catalyzes conversion of androstenedione & testosterone to estrone & estradiol, the rate limiting step in estrogen synthesis in peripheral tissues
Structure: belongs to the cytochrome P450 family
Compartment: membrane, peripheral membrane
Expression:
- expressed in brain, gonads, placenta
- granulosa cells within the ovary contain large amounts of aromatase
Pathology:
- defects in CYP19A1 are the cause of aromatase deficiency
Interactions
molecular events
Related
aromatase deficiency
cyp19A1 gene
gonadal steroid biosynthesis
granulosa cell
General
cytochrome P450
Properties
SIZE: entity length = 503 aa
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: Iron [Fe]-binding site
SITE: 436-436
Database Correlations
OMIM 107910
MORBIDMAP 107910
UniProt P11511
Entrez Gene 1588
ENZYME 1.14.14.1
References
- OMIM :accession 107910
- Kaiser Permanente Northern California Regional
Drug Formulary, Update 9/99
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Wikipedia; Aromatase entry
http://en.wikipedia.org/wiki/Aromatase
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP19A1
- UniProt :accession P11511