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angiotensin receptor neprilysin inhibitor (ARNI)
Indications:
- systolic heart failure Containdications:
- diastolic heart failure [3]
- use in combination with ACE inhibitor or ARB
Adverse effects:
- increases serum BNP (but decreases serum NT-proBNP) [2]
Interactions
drug interactions
Specific
sacubitril/valsartan (Entresto)
General
pharmacologic combination
References
- AGS Member Forum. May 28, 2018
The latest ACC/AHA/HFSA recommendations for Stage C HFrEF
- Velazquez EJ, Morrow DA, DeVore AD et al. PIONEER-HF Investigators
Angiotensin-neprilysin inhibition in acute decompensated heart failure.
N Engl J Med 2018 Nov 11.
PMID: 30415601
https://www.nejm.org/doi/10.1056/NEJMoa1812851
- Solomon SD, McMurray JJV, Anand IS et al.
Angiotensin-neprilysin inhibition in heart failure with preserved
ejection fraction.
N Engl J Med 2019 Sep 1;
PMID: 31475794
https://www.nejm.org/doi/10.1056/NEJMoa1908655
Components
angiotensin II receptor antagonist (ARB)
neprilysin inhibitor