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armadillo repeat-containing X-linked protein 2 (protein ALEX2, ARM protein lost in epithelial cancers on chromosome X 2, ARMCX2, ALEX2, KIAA0512)
Structure:
- contains 3 ARM repeats
Expression:
- expressed in ovary, heart, testis, prostate, brain, spleen, colon > liver, thymus
- not expressed in peripheral blood leukocytes, pancreas
Pathology:
- not expressed in ovarian carcinomas
General
armadillo repeat-containing X-linked protein
membrane protein
Properties
SIZE: MW = 66 kD
entity length = 632 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {7-25}
alanine-rich region {77-277}
MOTIF: alanine residue (SEVERAL)
ARM repeat {376-416}
ARM repeat {418-457}
ARM repeat {498-537}
Database Correlations
OMIM 300363
UniProt Q7L311
Pfam PF04826
References
- UniProt :accession Q7L311
- Atlas of Genetics and Cytogenetics in Oncology and Haematology;
http://atlasgeneticsoncology.org/Genes/ALEX2Xq22ID478.html