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armadillo repeat-containing X-linked protein 1 (protein ALEX1, ARM protein lost in epithelial cancers on chromosome X 1, ARMCX1, ALEX1, AD032)
Structure:
- contains 3 ARM repeats
Expression:
- expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon
- expressed at very low levels in liver & thymus
- not expressed in peripheral blood leukocytes
- low or not expression in lung, prostate, colon, pancreas
Pathology:
- low or no expression in ovarian carcinomas
General
armadillo repeat-containing X-linked protein
membrane protein
Properties
SIZE: MW = 49 kD
entity length = 453 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {7-29}
ARM repeat {195-235}
ARM repeat {237-276}
ARM repeat {358-398}
Database Correlations
OMIM 300362
UniProt Q9P291
Pfam PF04826
References
- UniProt :accession Q9P291
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/ALEX1Xq22ID477.html