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ADP-ribosylation factor-like protein 6; Bardet-Biedl syndrome 3 protein (ARL6)

Function: - interacts with SEC61B, ARL6IP1, ARL6IP2, ARL6IP3, ARL6IP4 ARL6IP5 & ARL6IP6 (putative) Structure: - belongs to the small GTPase superfamily, Arf family Compartment: cytoplasm (putative) Pathology: - defects in ARL6 are a cause of Bardet-Biedl syndrome type 3

Related

ARL-6-interacting protein 1; ADP-ribosylation-like factor 6-interacting protein 1; Aip-1 (ARL6IP, ARL6IP1, KIAA0069)

General

ADP-ribosylation factor-like protein (ARL)

Properties

SIZE: entity length = 186 aa MW = 21 kD COMPARTMENT: cytoplasm MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate GTP-binding site SITE: 24-31 MOTIF: Mg+2-binding site SITE: 31-31 Mg+2-binding site SITE: 50-50 MOTIF: binding site SITE: 50-50 FOR-BINDING-OF: GTP GTP-binding site SITE: 69-73 MOTIF: binding site SITE: 72-72 FOR-BINDING-OF: GTP; via amide nitrogen GTP-binding site SITE: 130-133 binding site SITE: 164-164 FOR-BINDING-OF: GTP; via amide nitrogen

Database Correlations

OMIM correlations MORBIDMAP 608845 UniProt Q9H0F7 Pfam PF00025 Entrez Gene 84100 Kegg hsa:84100

References

  1. UniProt :accession Q9H0F7
  2. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/ARL6