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ADP-ribosylation factor-like protein 2 (ARL2)
Function:
- GTP-binding protein
- component of a regulated secretory pathway involved in Ca+2-dependent release of acetylcholine
- regulates formation of new microtubules
- required for normal progress through the cell cycle
- interacts with SCOC & ELMOD2
- GTP-bound form interacts with ARL2BP
Structure: belongs to the small GTPase superfamily, Arf family
Compartment: centrosome
Pathology:
- does not act as an allosteric activator of the cholera toxin catalytic subunit
General
ADP-ribosylation factor-like protein (ARL)
Properties
SIZE: entity length = 184 aa
MW = 21 kD
COMPARTMENT: cellular membrane
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
GTP-binding site
SITE: 23-30
GTP-binding site
SITE: 66-70
MOTIF: GTP-binding site
SITE: 68-68
GTP-binding site
SITE: 125-128
Database Correlations
OMIM 601175
UniProt P36404
Pfam PF00025
Entrez Gene 402
Kegg hsa:402
References
- UniProt :accession P36404
- Entrez Gene :accession 402