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ariadne-1 protein homolog; ARI-1; ubiquitin-conjugating enzyme E2-binding protein 1; UbcH7-binding protein; UbcM4-interacting protein; HHARI; H7-AP2; monocyte protein 6; MOP-6 (ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27)
Function:
- might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, & then transfers it to substrates
- interacts with UBE2L3
Structure:
- belongs to the RBR family, Ariadne subfamily
- contains 1 IBR-type Zn+2 finger
- contains 2 RING-type Zn+2 fingers
Compartment: cytoplasm (mainly cytoplasmic)
Expression: widely expressed
Related
ubiquitin (UBCEP2, UBB, UBC)
General
ring finger protein
Properties
SIZE: entity length = 557 aa
MW = 64 kD
COMPARTMENT: cytoplasm
MOTIF: acidic region {10-38}
MOTIF: acidic residue (SEVERAL)
glycine-rich region {51-92}
UBE2L3 interaction {186-254}
MOTIF: RING-finger {186-236}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 256-317
EFFECTOR-BOUND: Zn+2
RING-finger {344-375}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
coiled coil {433-449}
Database Correlations
OMIM 605624
UniProt Q9Y4X5
Pfam PF01485
Entrez Gene 25820
Kegg hsa:25820
References
- UniProt :accession Q9Y4X5
- Entrez Gene :accession 25820