AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B, histone deacetylase complex subunit SAP180, 180 kD Sin3-associated polypeptide, Sin3-associated polypeptide p180, Retinoblastoma-binding protein 1-like 1, breast cancer-associated antigen BRCAA1, ARID4B, BRCAA1, RBBP1L1, RBP1L1, SAP180)

Function: - transcriptional repressor - role in assembly &/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex & other regulatory complexes - component of a Sin3A corepressor complex Structure: - contains 1 ARID domain involved in stabilizing the mSin3A corepressor complex on DNA - C-terminus mediates interaction with mSin3A corepressor complex - N-terminus is involved in transcriptional repression by HDAC-independent mechanisms Compartment: - nucleus, cytoplasm - cytoplasmic in breast cancer cells Alternative splicing: named isoforms=4 Expression: - highly expressed in the testis - expressed at low levels in the thymus, prostate & ovary Pathology: - highly expressed in breast cancer, lung cancer, colon cancer, pancreatic cancer & ovarian cancer

General

AT-rich interactive domain-containing protein (ARID domain-containing protein, ARID) transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 148 kD entity length = 1312 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: serine-rich region {154-159} MOTIF: serine residue (SEVERAL) glutamate-rich region {268-567} MOTIF: glutamate residue (SEVERAL) ARID {306-398} Antigenic epitope {465-473} Ser phosphorylation site {S710} Ser phosphorylation site {S712} Ser phosphorylation site {S713} Ser phosphorylation site {S717} coiled coil {728-754} Thr phosphorylation site {T1022} Ser phosphorylation site {S1029} serine-rich region {1095-1101} MOTIF: serine residue (SEVERAL) Antigenic epitope {1130-1137} coiled coil {1231-1270} serine-rich region {1271-1303} MOTIF: serine residue (SEVERAL)

Database Correlations

UniProt Q4LE39 PFAM correlations

References

UniProt :accession Q4LE39