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AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B, bright-like, bright & dead ringer protein, ARID3B, BDP, DRIL2)
Function:
- transcription factor
- favors nuclear targeting of ARID3A
- heterodimer with ARID3A
- interacts with unphosphorylated RB1
Structure: contains 1 ARID domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in placenta, testis & leukocytes
Pathology:
- expressed in neuroblastoma
- role in neuroblastoma growth & malignant transformation (putative)
- present in K562 erythrocytic leukemia cells (at protein level)
General
AT-rich interactive domain-containing protein (ARID domain-containing protein, ARID)
Properties
SIZE: MW = 61 kD
entity length = 561 aa
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {5-49}
MOTIF: glutamine residue (SEVERAL)
interaction with RB1 {203-365}
MOTIF: ARID {215-307}
alanine-rich region {341-353}
MOTIF: alanine residue (SEVERAL)
interaction with ARID3A {490-513}
serine-rich region {523-560}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q8IVW6
Pfam PF01388
References
UniProt :accession Q8IVW6