AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B, Osa homolog 2, hOsa2, p250R, BRG1-binding protein hELD/OSA1, BRG1-associated factor 250b, BAF250B, ARID1B, DAN15, KIAA1235, OSA2)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - binds DNA non-specifically - component of SWI/SNF chromatin remodeling complexes a) SWI/SNF-A complex b) SWI/SNF-B complex c) SWI/SNF-like EPAFb complex - interacts through its C- terminus with SMARCA2& SMARCA4 - interacts with SMARCC1 Structure: contains 1 ARID domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - widely expressed - high levels in heart, skeletal muscle & kidney Note: uncertain whether Met-1 or Met-59 is the initiator

Properties

COMPARTMENT: NUCL :NAME ARID MOTIF: DNA-binding motif

Database Correlations

UniProt Q8NFD5 Pfam PF01388

References

UniProt :accession Q8NFD5