Rho GTPase-activating protein 8 (ARHGAP8)

Function: - GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (putative) Structure: - contains 1 CRAL-TRIO domain - contains 1 Rho-GAP domain Alternative splicing: named isoforms=3 Expression: - highly expressed in kidney & placenta - also expressed in colon, skeletal muscle, small intestine, stomach, & testis - not detected in brain, liver or spleen Pathology: - overexpressed in majority of colorectal tumors examined

Properties

SIZE: entity length = 464 aa MW = 53 kD MOTIF: CRAL-TRIO lipid binding domain {13-199} rho-GAP domain NAME: rho-GAP domain SITE: 226-412

Database Correlations

UniProt P85298 Pfam PF00620

References

UniProt :accession P85298