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Rho GTPase-activating protein 29 (Rho-type GTPase-activating protein 29, PTPL1-associated RhoGAP protein 1, ARHGAP29, PARG1)
Function:
- GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
- strong activity toward RHOA, & weaker activity toward RAC1 & CDC42
- may act as a specific effector of RAP2A to regulate Rho
- interacts with PTPN13/PTPL1
- interacts with RAP2A via its coiled coil domain
Structure:
- contains 1 phorbol-ester/DAG-type Zn+2 finger
- contains 1 Rho-GAP domain
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highly expressed in skeletal muscle & heart
- expressed at intermediate level in placenta, liver & pancreas
- weakly expressed in brain, lung & kidney
Pathology:
- strongly down-regulated in mantle-cell lymphomas
- up-regulated in migrating glioma cells
General
phosphoprotein
rho GTPase-activating protein (rho-GAP)
zinc finger protein
Properties
SIZE: entity length = 1261 aa
MW = 142 kD
MOTIF: Ser phosphorylation site {S176}
Ser phosphorylation site {S179}
coiled coil {296-418}
Zinc finger
NAME: Zinc finger
SITE: 612-657
EFFECTOR-BOUND: Zn+2
rho-GAP domain
NAME: rho-GAP domain
SITE: 671-886
Ser phosphorylation site {S913}
Ser phosphorylation site {S1019}
PTPN13/PTPL1 interaction {1258-1261}
Database Correlations
UniProt Q52LW3
PFAM correlations
Kegg hsa:9411
References
UniProt :accession Q52LW3