Rho GTPase-activating protein 27 (Rho-type GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, ARHGAP27, CAMGAP1, PP905)

Function: - Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis - GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state - has activity toward CDC42 & RAC1 (putative) - interacts with SH3KBP1/CIN85 (putative) Structure: contains 1 PH domain contains 1 Rho-GAP domain contains 1 SH3 domain contains 3 WW domains Compartment: - cytoplasm (putative), peripheral membrane (putative) Alternative splicing: named isoforms=4 Expression: - expressed in germinal center B-cell, spleen Pathology: - expressed in chronic lymphocytic leukemia, pancreatic cancer & lung cancer

General

phosphoprotein rho GTPase-activating protein (rho-GAP)

Properties

SIZE: entity length = 889 aa MW = 98 kD COMPARTMENT: cytoplasm MOTIF: src homology 3 [SH3] domain SITE: 8-69 Ser phosphorylation site {S216} Tyr phosphorylation site {Y228} WW domain (W/rsp5/WWP domain) {246-280} WW domain (W/rsp5/WWP domain) {299-333} WW domain (W/rsp5/WWP domain) {411-444} PH domain {496-612} Ser phosphorylation site {S638} rho-GAP domain NAME: rho-GAP domain SITE: 697-886

Database Correlations

UniProt Q6ZUM4 PFAM correlations Kegg hsa:2011

References

UniProt :accession Q6ZUM4