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Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; oligophrenin-1-like protein; Rho-type GTPase-activating protein 26 (ARHGAP26, GRAF, KIAA0621, OPHN1L)
Function:
- GTPase-activating protein for RHOA & CDC42
- binds to the C-terminus of PTK2/FAK
Structure:
- contains 1 PH domain
- contains 1 Rho-GAP domain
- contains 1 SH3 domain
Compartment:
- cell junction, focal adhesion
- cytoplasm, cytoskeleton (putative)
- colocalizes with actin stress fibers & cortical actin structures (putative)
Alternative splicing: named isoforms=2
Pathology:
- defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia
General
rho GTPase-activating protein (rho-GAP)
Properties
SIZE: entity length = 814 aa
MW = 92 kD
COMPARTMENT: cytoplasm
MOTIF: PH domain {265-369}
rho-GAP domain
NAME: rho-GAP domain
SITE: 383-568
MOTIF: Thr phosphorylation site {T402}
serine-rich region {584-701}
MOTIF: serine residue (SEVERAL)
src homology 3 [SH3] domain
SITE: 756-814
Database Correlations
OMIM correlations
MORBIDMAP 605370
UniProt Q9UNA1
PFAM correlations
Entrez Gene 23092
Kegg hsa:23092
References
- UniProt :accession Q9UNA1
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GRAFID291.html
- Wikipedia; Note: Graf1 entry
http://en.wikipedia.org/wiki/Graf1