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Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23, ARHGAP23, KIAA1501)
Function:
- GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
Structure:
- contains 1 PDZ domain (DHR domain)
- contains 1 PH domain
- contains 1 Rho-GAP domain
Alternative splicing: named isoforms=2
Expression:
- expressed in placenta, prostate, hippocampus, medulla
Pathology:
- expressed in brain tumors, salivary gland tumor, head & neck cancer
General
rho GTPase-activating protein (rho-GAP)
Properties
SIZE: MW = 162 kD
entity length = 1491 aa
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 71-155
proline-rich region
SITE: 183-279
MOTIF: proline residue (SEVERAL)
PH domain {688-808}
rho-GAP domain
NAME: rho-GAP domain
SITE: 905-1097
arginine-rich region {1320-1405}
MOTIF: arginine residue (SEVERAL)
Database Correlations
UniProt Q9P227
PFAM correlations
References
UniProt :accession Q9P227