Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22, ARHGAP22, RHOGAP2)

Function: - Rho GTPase-activating protein - role in signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis - GTPase activator for RAC1 by converting it to an inactive GDP-bound state - inhibits RAC1-dependent lamellipodia formation - role in transcription regulation via interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter - interacts with VEZF1 Structure: - contains 1 PH domain - contains 1 Rho-GAP domain Compartment: - cytoplasm, nucleus - mainly cytoplasmic, some fraction is nuclear Alternative splicing: named isoforms=4

Properties

SIZE: MW = 77 kD entity length = 698 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: PH domain {37-145} rho-GAP domain NAME: rho-GAP domain SITE: 155-349 serine-rich region {427-587} MOTIF: serine residue (SEVERAL) coiled coil {590-687}

Database Correlations

UniProt Q7Z5H3 PFAM correlations

References

UniProt :accession Q7Z5H3