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Rho GTPase-activating protein 18 (MacGAP, ARHGAP18)
Function:
- GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
- interacts with MPHOSPH6
Structure: contains 1 Rho-GAP domain
Alternative splicing: named isoforms=2
General
rho GTPase-activating protein (rho-GAP)
Properties
SIZE: MW = 27.5 kD
MOTIF: phosphorylation site
domain {C-TERMINAL}
MOTIF: active site
binding site
FOR-BINDING-OF: rho subfamily protein
HOMOLOGY: p160BCR
beta-chimaerin
n-chimaerin
Rho-GTPase-activating protein 5
rho-GAP
SH3 domain-binding protein 1
PI-3-kinase p85
drosophila rotund protein
Database Correlations
UniProt Q8N392
Pfam PF00620
References
UniProt :accession Q8N392