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ADP-ribosylation factor 6 (ARF6)
Function:
- GTP-binding protein
- activates ADP-ribosyltransferase (putative)
- role in protein trafficking
- may modulate vesicle budding & uncoating within the Golgi
- may function in receptor-mediated endocytosis [3]
- interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C & UACA
Structure: belongs to the small GTPase superfamily, Arf family
Compartment: Golgi apparatus
Pathology:
- allosteric activator of the cholera toxin catalytic subunit
General
ADP-ribosylation factor [ARF] subfamily protein
Properties
SIZE: entity length = 175 aa
MW = 20 kD
COMPARTMENT: golgi
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
GTP-binding site
SITE: 20-27
GTP-binding site
SITE: 63-67
GTP-binding site
SITE: 122-125
Database Correlations
OMIM 600464
UniProt P62330
Pfam PF00025
Entrez Gene 382
Kegg hsa:382
References
- UniProt :accession P62330
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- D'Souza-Schorey C, Li G, Colombo MI, Stahl PD.
A regulatory role for ARF6 in receptor-mediated endocytosis.
Science. 1995 Feb 24;267(5201):1175-8.
PMID: 7855600
- Entrez Gene :accession 382