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ADP-ribosylation factor 3 (ARF3)
Function:
- GTP-binding protein
- activates ADP-ribosyltransferase (putative)
- role in protein trafficking
- may modulate vesicle budding & uncoating within the Golgi
- interacts with PRKCABP
Structure: belongs to the small GTPase superfamily, Arf family
Compartment: Golgi
Pathology:
- allosteric activator of the cholera toxin catalytic subunit
General
ADP-ribosylation factor [ARF] subfamily protein
Properties
SIZE: entity length = 181 aa
MW = 21 kD
COMPARTMENT: golgi
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
GTP-binding site
SITE: 24-31
GTP-binding site
SITE: 67-71
GTP-binding site
SITE: 126-129
Database Correlations
OMIM 103190
UniProt P61204
Pfam PF00025
Entrez Gene 377
Kegg hsa:377
References
- UniProt :accession P61204
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Entrez Gene :accession 377