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antoxidant-response element (ARE)

Mediates transcription of genes in cells exposed to oxidative stress via the transcription factor Nrf2. Genes encoding antioxidant enzymes as well as phase 2 detoxification enzymes appear to contain the ARE. Activation of genes containing the ARE is induced by electrophilic compounds & phenolic antioxidants. Nrf2 upregulates genes containing the ARE perhaps as a hetero- dimer with small maf proteins lacking the transcriptional activation domain [1]. maf proteins including c-maf & small mafs (G-maf) appear to down-regulate genes containing the ARE [2].

Related

nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; nuclear factor, erythroid derived 2, like 2; HEBP1 (NFE2L2 NRF2)

General

promoter element

Properties

NAME: antioxidant-response element FOR-BINDING-OF: nuclear factor erythroid 2-related factor 2 MISC-INFO: consensus

References

  1. Nguyen T et al Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol. 2003;43:233-60. Review. PMID: 12359864
  2. Dhakshinamoorthy S & Jaiswal AK c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction. Oncogene 21:5301, 2002 PMID: 12149651