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nuclear receptor coactivator 4; NCoA-4; androgen receptor-associated protein of 70 kDa; androgen receptor coactivator 70 kD protein; 70 kD androgen receptor coactivator; 70 kD AR-activator; Ret-activating protein ELE1 (NCOA4, ARA70, ELE1, RFG)
Function:
- enhances the androgen receptor transcriptional activity in prostate cancer cells
- ligand-independent coactivator of PPAR-gamma
- interacts with the androgen receptor & the retinoid X receptor (RXR) (ligand-dependent)
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- detected in adipose tissues & in different cell lines
- isoform beta is only expressed in testis
Pathology:
- chromosomal inversion inv(10)(q11.2;q11.2) involving NCOA4 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]
- the inversion generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic & radiation-associated post-Chernobyl thyroid papillary carcinomas
Related
nuclear hormone receptor family
General
nuclear (steroid) receptor coactivator (NRC, SRC, NCoA)
phosphoprotein
Properties
SIZE: entity length = 614 aa
MW = 70 kD
MOTIF: breakpoint {238-239}
Ser phosphorylation site {S456}
Database Correlations
OMIM correlations
UniProt Q13772
Pfam PF12489
Entrez Gene 8031
Kegg hsa:8031
References
- UniProt :accession Q13772
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/NCOA4ID218ch10q11.html