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anistreplase (APSAC, Eminase)
Tradename: APSAC, Eminase.
Anisoylated plasminogen-streptokinase complex. Requires spontaneous deacylation prior to activation of plasminogen by the streptokinase.
Dosage: 30 units IV over 2-5 minutes.
General
enzymatic agent
fibrinolytic agent (thrombolytic agent)
Properties
MISC-INFO: elimination route LIVER
pregnancy-category C
safety in lactation ?
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 95