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apoptosome complex
Function:
- multimeric scaffold/procaspase complex.
- the "initiation complex" of apoptosis
- ssembly is regulated by bcl-2 family of proteins.
Structure:
- consists of at least
a) APAF1
b) caspase-9 (proenzyme)
c) UACA
Related
apoptosis
General
macromolecular complex
References
- Adams JM, Cory S.
Life-or-death decisions by the Bcl-2 protein family.
Trends Biochem Sci. 2001 Jan;26(1):61-6. Review.
PMID: 11165519
- UniProt :accession Q9BZF9
Components
apoptotic protease-activating factor 1; APAF-1 (APAF1, KIAA0413)
caspase-9; ice-like apoptotic protease 6; ICE-LAP6; apoptotic protease MCH-6 (CASP9, MCH6)
uveal autoantigen with coiled-coil domains & ankyrin repeats protein (UACA, KIAA1561)