pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1, PH & FYVE domain-containing protein 1, phafin-1, lysosome-associated apoptosis-inducing protein containing PH & FYVE domains, apoptosis-inducing protein, zinc finger FYVE domain-containing protein 15, PLEKHF1, APPD, LAPF, ZFYVE15)

Function: 1) may induce apoptosis through the lysosomal-mitochondrial pathway 2) translocates to the lysosome initiating permeabilization of lysosomal membrane resulting in release of CTSD & CTSL into cytoplasm 3) triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization resulting in release of PDCD8 Compartment: - nucleus, cytoplasm, perinuclear region, lysosome - translocates to lysosome during apoptosis Expression: - expressed in heart, skeletal muscle > brain, thymus, spleen, kidney, liver, small intestine, placenta, lung

General

pleckstrin homology domain containing family zinc finger FYVE domain-containing protein (ZFYVE)

Properties

SIZE: MW = 31 kD entity length = 279 aa COMPARTMENT: cell nucleus MOTIF: PH domain {35-131} Zn finger Fyve-type SITE: 152-212 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q96S99 PFAM correlations

References

UniProt :accession Q96S99