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beta-2-glycoprotein 1; APC inhibitor; activated protein C-binding protein; anticardiolipin cofactor; apolipoprotein H; apo-H; beta-2-glycoprotein I; B2GPI; beta(2)GPI (APOH, B2G1)
Function:
- binds to various kinds of negatively charged substances such as heparin, phospholipids, & dextran sulfate
- may prevent activation of the intrinsic coagulation cascade by binding to phospholipids on the surface of damaged cells
Structure:
- N- & O-glycosylated
- contains 4 Sushi (CCP/SCR) domains
Compartment: secreted
Expression:
- expressed in liver & secreted into plasma
Pathology:
- autoantibody in antiphospholipid syndrome
Laboratory:
- beta-2 glycoprotein-1 Ab in serum
- beta-2 glycoprotein-1 IgA in serum
- beta-2 glycoprotein-1 IgG in serum
- beta-2 glycoprotein-1 IgM in serum
General
apolipoprotein
beta 2 globulin
Properties
SIZE: entity length = 345 aa
MW = 38 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-19}
Sushi domain {21-81}
MOTIF: cysteine residue {C23}
MODIFICATION: cysteine residue {C66}
cysteine residue {C51}
MODIFICATION: cysteine residue {C79}
cysteine residue {C66}
MODIFICATION: cysteine residue {C23}
cysteine residue {C79}
MODIFICATION: cysteine residue {C51}
Sushi domain {82-139}
MOTIF: cysteine residue {C84}
MODIFICATION: cysteine residue {C124}
cysteine residue {C110}
MODIFICATION: cysteine residue {C137}
cysteine residue {C124}
MODIFICATION: cysteine residue {C84}
cysteine residue {C137}
MODIFICATION: cysteine residue {C110}
Sushi domain {140-202}
MOTIF: cysteine residue {C142}
MODIFICATION: cysteine residue {C188}
Thr glycosylation site {T149}
N-glycosylation site {N162}
cysteine residue {C174}
MODIFICATION: cysteine residue {C200}
N-glycosylation site {N183}
cysteine residue {C188}
MODIFICATION: cysteine residue {C142}
N-glycosylation site {N193}
cysteine residue {C200}
MODIFICATION: cysteine residue {C174}
Sushi domain {203-262}
MOTIF: cysteine residue {C205}
MODIFICATION: cysteine residue {C248}
cysteine residue {C234}
MODIFICATION: cysteine residue {C260}
cysteine residue {C248}
MODIFICATION: cysteine residue {C205}
N-glycosylation site {N253}
cysteine residue {C260}
MODIFICATION: cysteine residue {C234}
Sushi-like {263-345}
MOTIF: cysteine residue {C264}
MODIFICATION: cysteine residue {C315}
cysteine residue {C300}
MODIFICATION: cysteine residue {C325}
cysteine residue {C307}
MODIFICATION: cysteine residue {C345}
cysteine residue {C315}
MODIFICATION: cysteine residue {C264}
cysteine residue {C325}
MODIFICATION: cysteine residue {C300}
cysteine residue {C345}
MODIFICATION: cysteine residue {C307}
Database Correlations
OMIM 138700
UniProt P02749
PFAM correlations
Entrez Gene 350
Kegg hsa:350
References
- UniProt :accession P02749
- SeattleSNPs
http://pga.gs.washington.edu/data/apoh/
- SHMPD; Singapore Human Mutation and Polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOH