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apolipoprotein A2 (APOA2)
Function:
- structural protein of HDL
- function of apo A2 is not entirely clear; however, it appears to play a play a stuctural role in HDL & a role in activation of triglyceride lipase & inhibition of LCAT
- Met-49 is oxidized to methionine sulfoxide
- phosphorylation sites are present in plasma
- forms a disulfide- linked heterodimer with APOD
- interacts with HCV core protein
- interacts with APOA1BP & NDRG1
Structure:
- homodimer, disulfide-linked
- belongs to the apolipoprotein A2 family
Compartment: secreted
Expression:
- synthesized in liver & intestine
- secreted into plasma
General
apolipoprotein A
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 100 aa
MW = 11 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-18}
cysteine residue {C29}
MODIFICATION: cysteine residue {C136 IN APOD); IN HETERODIMERIC FORM}
cysteine residue {C29}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Ser phosphorylation site {S32}
Ser phosphorylation site {S35}
Ser phosphorylation site {S68}
MISC-INFO: CONCENTRATION 25-55 MG/DL
1/2life 2-5 DAYS
Database Correlations
OMIM 107670
UniProt P02652
Pfam PF04711
Entrez Gene 336
Kegg hsa:336
References
- Primary Hyperlipoproteinemias, Steiner & Shafrir (eds),
McGraw Hill, NY, 1991, pg 24
- Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993, pg 1021
- Entrez Gene :accession 336
- UniProt :accession P02652
- SHMPD; Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2
Component-of
chylomicron