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apolipoprotein A5; apo-AV; apoA-V; regeneration-associated protein 3 (APOA5, RAP3, UNQ411/PRO773)
Function:
- associates with HDL, & to a lesser extent VLDL & chylomicrons
- thought to be important determinant of plasma triglycerides
- stimulates of apo-CII lipoprotein lipase
- inhibits of the hepatic VLDL-triglyceride production
- activates poorly lecithin:cholesterol acyltransferase (LCAT)
- phosphorylation sites are present in plasma
- interacts with GPIHBP1
Structure: belongs to the apolipoprotein A1/A4/E family
Compartment: secreted
Expression:
- expressed by liver & secreted into plasma
- up-regulated by PPARA agonists
- induced in early phase of liver regeneration
Polymorphism:
- 3 common alleles are known: allele APOA5*1, APOA5*2 & APOA5*3.
Pathology:
- defects in APOA5 are a cause of
- susceptibility to familial hypertriglyceridemia
- hyperlipoproteinemia type 5
Note:
- uncertain whether Met-1 or Met-4 is the initiator
Related
hyperlipoproteinemia type 5
General
apolipoprotein A
phosphoprotein
Properties
SIZE: entity length = 366 aa
MW = 41 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-23}
coiled coil {54-157}
MOTIF: Thr phosphorylation site {T55}
Ser phosphorylation site {S59}
coiled coil {236-262}
Database Correlations
OMIM correlations
MORBIDMAP 606368
UniProt Q6Q788
Pfam PF01442
Entrez Gene 116519
Kegg hsa:116519
References
- UniProt :accession Q6Q788
- Entrez Gene :accession 116519