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apo e3
Allelic form of apo E; wildtype or most frequent form.
Structure:
- Cys :site C112
- Met :site M125
- Arg :site R158
Laboratory:
- apolipoprotein E3 in blood
Properties
GENERAL: apolipoprotein E
RELATED: apolipoprotein E genotype
apolipoprotein-E gene
SIZE: entity length = 317 aa
MW = 36 kD
COMPARTMENT: extracellular compartment
FORM: apo e3
MOTIF: signal sequence {1-18}
consensus repeat {80-101}
consensus repeat {102-123}
consensus repeat {124-145}
consensus repeat {146-167}
Ser phosphorylation site {S147}
LDL receptor binding {158-168}
MOTIF: binding site
SITE: 162-165
FOR-BINDING-OF: heparin
consensus repeat {168-189}
consensus repeat {190-211}
consensus repeat {212-233}
Thr glycosylation site {T212}
binding site
SITE: 229-236
FOR-BINDING-OF: heparin
consensus repeat {234-255}
Thr glycosylation site {T307}
Ser glycosylation site {S308}
SECRETED-BY: hepatocyte
astrocyte
WITHIN: central nervous system
COMPONENT-OF: chylomicron
MISC-INFO: CONCENTRATION 2-6 MG/DL
References
- OMIM :accession 107741
- Strittmatter WJ et al
Apolipoprotein E: high-avidity binding to beta-amyloid and
increased frequency of type 4 allele in late-onset familial
Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81
PMID: 8446617
Databases & Figures
OMIM correlations
MORBIDMAP 107741
UniProt P02649
Pfam PF01442
Entrez Gene 348
Kegg hsa:348
ApoE allele frequencies