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apo e1
ApoE2, apoE3, & apoE4 are alleles from a single gene. Is apoE1 is from a different gene?
Laboratory:
- apolipoprotein E1 in blood
Properties
GENERAL: apolipoprotein E
RELATED: apolipoprotein E genotype
apolipoprotein-E gene
SIZE: entity length = 317 aa
MW = 36 kD
COMPARTMENT: extracellular compartment
FORM: apo e1
MOTIF: signal sequence {1-18}
consensus repeat {80-101}
consensus repeat {102-123}
consensus repeat {124-145}
consensus repeat {146-167}
Ser phosphorylation site {S147}
LDL receptor binding {158-168}
MOTIF: binding site
SITE: 162-165
FOR-BINDING-OF: heparin
consensus repeat {168-189}
consensus repeat {190-211}
consensus repeat {212-233}
Thr glycosylation site {T212}
binding site
SITE: 229-236
FOR-BINDING-OF: heparin
consensus repeat {234-255}
Thr glycosylation site {T307}
Ser glycosylation site {S308}
SECRETED-BY: hepatocyte
astrocyte
WITHIN: central nervous system
COMPONENT-OF: chylomicron
MISC-INFO: CONCENTRATION 2-6 MG/DL
Database Correlations
OMIM correlations
MORBIDMAP 107741
UniProt P02649
Pfam PF01442
Entrez Gene 348
Kegg hsa:348
References
Clinical Laboratory Medicine, Tilton et al (eds),
Mosby Year Book, St. Louis, 1992, pg 129