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apolipoprotein C2; apo-CII (APOC2, APC2)

Function: - component of VLDL - activator of several triacylglycerol lipases - association of APOC2 with plasma chylomicrons, VLDL, & HDL is reversible, a function of the secretion & catabolism of triglyceride-rich lipoproteins, & changes rapidly - inhibits binding of VLDL & chylomicrons to hepatic receptors thus targeting them for extrahepatic clearance Structure: belongs to the apolipoprotein C2 family Compartment: secreted Expression: secreted in plasma Pathology: - defects in APOC2 are the cause of hyperlipoproteinemia type 1B

Related

apoc2 gene

General

apolipoprotein C

Properties

SIZE: entity length = 101 aa MW = 11 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-22} Lipid binding {43-51} Lipoprotein lipase cofactor {55-78} MISC-INFO: 1/2life 10-18 HOURS

Database Correlations

OMIM correlations UniProt P02655 Pfam PF05355 Entrez Gene 344 Kegg hsa:344

References

  1. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1022
  2. Entrez Gene :accession 344
  3. UniProt :accession P02655
  4. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/APOC2