autophagy 4 homolog D; cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; autophagin-4; autophagy-related cysteine endopeptidase 4; autophagy-related protein 4 homolog D (ATG4D APG4D AUTL4)

Function: - cysteine protease required for autophagy - cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I - a subpopulation of form I is subsequently converted to a smaller form (form II) - form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes Inhibition: - inhibited by N-ethylmaleimide Structure: belongs to the peptidase C54 family Compartment: cytoplasm (probable) Expression: - mainly expressed in skeletal muscle - expressed, to a lesser extent, in testis

General

autophagy protein (autophagy-related protein) cysteine proteinase; thiol proteinase

Properties

SIZE: entity length = 474 aa MW = 53 kD COMPARTMENT: cytoplasm MOTIF: cysteine residue {C144} active site MOTIF: cysteine residue aspartate residue {D356} histidine residue {H358}

Database Correlations

OMIM 611340 UniProt Q86TL0 Pfam PF03416 Entrez Gene 84971 Kegg hsa:84971

References

UniProt :accession Q86TL0