autophagy 4 homolog C Cysteine protease ATG4C; EC=3.4.22.-; AUT-like 3 cysteine endopeptidase; autophagin-3; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C (ATG4C, APG4C, AUTL1, AUTL3)

Function: - cysteine protease required for autophagy - cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I - a subpopulation of form I is subsequently converted to a smaller form (form II) - form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes Inhhibition: - inhibited by N-ethylmaleimide Structure: belongs to the peptidase C54 family Compartment: cytoplasm (probable) Expression: - highly expressed in skeletal muscle, heart, liver & testis

General

autophagy protein (autophagy-related protein) cysteine proteinase; thiol proteinase

Properties

SIZE: entity length = 458 aa MW = 52 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl cysteine residue {C111} active site MOTIF: cysteine residue aspartate residue {D345} histidine residue {H347}

Database Correlations

OMIM 611339 UniProt Q96DT6 Pfam PF03416 Entrez Gene 84938 Kegg hsa:84938

References

UniProt :accession Q96DT6