autophagy 4 homolog B; cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; autophagin-1; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; hAPG4B (ATG4B, APG4B, AUTL1, KIAA0943)

Function: - cysteine protease required for autophagy - cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I - a subpopulation of form I is subsequently converted to a smaller form (form II) - form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes Inhibition: - inhibited by N-ethylmaleimide Structure: belongs to the peptidase C54 family Compartment: cytoplasm (probable) Alternative splicing: named isoforms=5 Expression: - expressed in the skeletal muscle > brain, heart, liver & pancreas

General

autophagy protein (autophagy-related protein) cysteine proteinase; thiol proteinase phosphoprotein

Properties

SIZE: entity length = 393 aa MW = 44 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S34} cysteine residue {C74} aspartate residue {D278} histidine residue {H280} Ser phosphorylation site {S316} Ser phosphorylation site {S383} Ser phosphorylation site {S392}

Database Correlations

OMIM 611338 UniProt Q9Y4P1 Pfam PF03416 Entrez Gene 23192 Kegg hsa:23192

References

UniProt :accession Q9Y4P1