autophagy 4 homolog A; cysteine protease ATG4A; AUT-like 2 cysteine endopeptidase; autophagin-2; autophagy-related cysteine endopeptidase 2; autophagy-related protein 4 homolog A; hAPG4A (ATG4A APG4A AUTL2)

Function: - cysteine protease required for autophagy - cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing liberation of form I - subpopulation of form I is subsequently converted to a smaller form (form II) - form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes - preferred substrate is GABARAPL2 followed by MAP1LC3A & GABARAP Inhibition: - inhibited by N-ethylmaleimide Structure: belongs to the peptidase C54 family Compartment: cytoplasm (probable) Alternative splicing: named isoforms=4 Expression: - widely expressed, at a low level - highest expression in skeletal muscle & brain - also detected in fetal liver

General

autophagy protein (autophagy-related protein) cysteine proteinase; thiol proteinase phosphoprotein

Properties

SIZE: entity length = 398 aa MW = 45 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S47} cysteine residue {C77} aspartate residue {D279} histidine residue {H281}

Database Correlations

OMIM 300663 UniProt Q8WYN0 Pfam PF03416 Entrez Gene 115201 Kegg hsa:115201

References

UniProt :accession Q8WYN0