apelin receptor; APJ receptor; G-protein coupled receptor APJ; angiotensin receptor-like 1; HG11 (APLNR, AGTRL1, APJ)

Function: - receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity (Gi proteins) Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - widely expressed in the brain, in glial cells, astrocytes & neuronal subpopulations - also expressed in spleen, thymus, ovary, small intestine & colon Pathology: - alternative coreceptor with CD4 for HIV-1 infection - may be involved in the development of AIDS dementia

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 380 aa MW = 43 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-26} MOTIF: N-glycosylation site {N15} transmembrane domain {27-51} cytoplasmic loop {52-66} transmembrane domain {67-91} exoplasmic loop {92-100} transmembrane domain {101-125} cytoplasmic loop {126-144} transmembrane domain {145-166} exoplasmic loop {167-200} MOTIF: N-glycosylation site {N175} transmembrane domain {201-221} cytoplasmic loop {222-244} transmembrane domain {245-271} exoplasmic loop {272-284} transmembrane domain {285-308} cytoplasmic domain {309-380}

Database Correlations

OMIM 600052 UniProt P35414 Pfam PF00001 Kegg hsa:187

References

UniProt :accession P35414