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Ca+2-binding mitochondrial carrier protein SCaMC-2 (small Ca+2-binding mitochondrial carrier protein 2, mitochondrial ATP-Mg/Pi carrier protein 3, mitochondrial Ca+2-dependent solute carrier protein 3, solute carrier family 25 member 25, SLC25A25, APC3, KIAA1896, MCSC3, SCAMC2, UNQ549/PRO1106)
Function:
- Ca+2-dependent mitochondrial solute carrier
- mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
- may act as ATP-Mg/Pi exchanger that mediates transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
Structure:
- belongs to the mitochondrial carrier family
- contains 3 EF-hand domains contains 3 solcar repeats
Compartment: mitochondrial inner membrane
Alternative splicing: named isoforms=6
Expression:
- present in various cell lines (at protein level)
- widely expressed
- expressed in fetal & adult liver, skeletal muscle, testis, ovary, hippocampus & caudate nucleus
- isoform 1 is present in all tissues tested
- isoform 2 is restricted to kidney & lung
General
Ca+2 binding protein
membrane protein
mitochondrial protein
solute carrier family 25 (SLC25, SLC25A)
Properties
SIZE: entity length = 469 aa
MW = 53 kD
COMPARTMENT: mitochondria
MOTIF: mitochondrial intermembrane {1-189}
MOTIF: EF hand
SITE: 47-80
Ca+2-binding site
SITE: 60-71
EF hand
SITE: 78-113
EF hand
SITE: 114-149
Solcar {184-270}
MOTIF: transmembrane domain {190-207}
mitochondrial matrix {208-244}
transmembrane domain {245-264}
mitochondrial intermembrane {265-287}
Solcar {278-363}
MOTIF: transmembrane domain {288-301}
mitochondrial matrix {302-337}
transmembrane domain {338-357}
mitochondrial intermembrane {358-380}
Solcar {375-463}
MOTIF: transmembrane domain {381-398}
mitochondrial matrix {399-437}
transmembrane domain {438-457}
mitochondrial intermembrane {458-469}
Database Correlations
OMIM 608745
UniProt Q6KCM7
PFAM correlations
References
UniProt :accession Q6KCM7