APBB1-interacting protein 1 (amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Rap1-GTP-interacting adapter molecule, RIAM, Proline-rich EVH1 ligand 1, PREL-1, proline-rich protein 73, retinoic acid-responsive proline-rich protein 1, RARP-1, APBB1IP, PREL1, RARP1, RIAM)

Function: 1) role in signal transduction from Ras activation to actin cytoskeletal remodelling 2) suppresses insulin-induced promoter activities through AP1b& SRE 3) mediates Rap1-induced adhesion 4) interacts, through the N-terminal Pro-rich region, with WW domain of APBB1 5) interacts with RAP1A, PFN1, VASP & ENAH Structure: - belongs to the MRL family - contains 2 Pro-rich regions required for suppression of AP1 transcription activity - contains 1 PH domain - contains 1 Ras-associating domain Compartment: - cell membrane - colocalizes with ENA/VASP proteins at lamellipodia tips & focal adhesions, & F-actin at the leading edge - at the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns-5-Phosphate & PtdIns-3-Phosphate - necessary for efficient interaction of RA domain with Ras-GTPases Expression: - widely expressed - high expression in thymus, spleen, lymph node, bone marrow & peripheral leukocytes - induced by all-trans-retinoic acid

General

membrane protein proline-rich protein

Properties

SIZE: MW = 73 kD entity length = 666 aa COMPARTMENT: cellular membrane MOTIF: proline-rich region SITE: 129-148 MOTIF: proline residue (SEVERAL) glutamate-rich region {152-155} MOTIF: glutamate residue (SEVERAL) Ras-associating {176-263} PH domain {310-419} proline-rich region SITE: 503-640 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q7Z5R6 PFAM correlations

References

UniProt :accession Q7Z5R6