AP-2 complex subunit alpha-2; adapter-related protein complex 2 alpha-2 subunit; adaptor protein complex AP-2 subunit alpha-2; alpha2-adaptin; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit; alpha-adaptin C; clathrin assembly protein complex 2 alpha-C large chain; 100 kD coated vesicle protein C; Huntingtin-interacting protein J; Huntingtin yeast partner J (AP2A2, ADTAB, CLAPA, HYPJ, KIAA0899)

Function: - subunit of clathrin-associated adaptor protein complex 2 (HA2-AP2 adaptor complex) - binds polyphosphoinositides (putative) - binds EPN1, EPS15, AMPH, SNAP91 & BIN1 (putative) - component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 & VIM Structure: belongs to the adaptor complexes large subunit family Compartment: - cell membrane, coated pit - peripheral membrane, cytoplasmic side - component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane

Related

clathrin (triskelion) HA2/AP2 adaptor complex

General

alpha adaptin (adaptor-related protein complex 2, alpha subunit, clathrin adaptor complex AP2, alpha subunit) phosphoprotein

Properties

SIZE: entity length = 939 aa MW = 104 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 5-80 FOR-BINDING-OF: lipid MOTIF: binding site SITE: 43-43 FOR-BINDING-OF: phosphatidylinositol binding site SITE: 53-53 FOR-BINDING-OF: phosphatidylinositol binding site SITE: 57-57 FOR-BINDING-OF: phosphatidylinositol binding site SITE: 58-58 FOR-BINDING-OF: phosphatidylinositol binding site SITE: 61-61 FOR-BINDING-OF: phosphatidylinositol Tyr phosphorylation site {Y808}

Database Correlations

OMIM 607242 UniProt O94973 PFAM correlations Entrez Gene 161 Kegg hsa:161

References

UniProt :accession O94973