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annexin A7; annexin-7; annexin VII; synexin (ANXA7, ANX7, SNX, OK/SW-cl95)
Function:
- Ca+2/phospholipid-binding protein
- promotes membrane fusion
- is involved in exocytosis
Structure:
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 4 annexin repeats
Alternative splicing: named isoforms=2
Expression:
- isoform 1 is expressed in brain, heart & skeletal muscle
- isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts & placenta
General
annexin
Properties
SIZE: entity length = 488 aa
MW = 53 kD
MOTIF: Repeat-rich region {1-143}
MOTIF: 3 X 5 AA tandem repeats of G-Y-P-P-X {5-20}
consensus repeat {5-9}
consensus repeat {10-14}
consensus repeat {16-20}
Annexin {189-254}
Ca+2-binding site
binding site
FOR-BINDING-OF: phospholipid
Annexin {266-326}
Annexin {349-409}
Annexin {425-485}
Database Correlations
OMIM 186360
UniProt P20073
Pfam PF00191
Entrez Gene 310
Kegg hsa:310
References
- UniProt :accession P20073
- Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL.
Calcium-activated endonexin II forms calcium channels across
acidic phospholipid bilayer membranes.
J Biol Chem. 1990 Dec 5;265(34):21207-15.
PMID: 2174439