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antipyrine/benzocaine otic (Auralgan, Auroto)

Benzocaine 1.4%, antipyrine 5.4% in glycerin* Indications: 1) temporary relief of ear pain a) otitis media b) otitis externa c) swimmer's ear 2) facilitation of ear wax removal - cerumen impactation Contraindications: sensitivity to ester-type local anesthetics Dosage: 1) 2-4 drops TID/QID PRN 2) insert saturated cotto pledget 3) for ear wax removal, instill drops TID-QID for 2-3 days 10 & 15 mL bottles. Adverse effects: (< 1%) 1) irritation 2) burning 3) hypersensitivity Mechanism of action: 1) anesthetic 2) decreased permeability of neuronal membrane to Na+ resulting in blocking of nerve impulses * New formulation substitutes acetic acid & U-polycosanol 410 for glycerin; price increases from $2 to $150 [4]

General

antipyrine/benzocaine otic agent; otologic agent; ear preparation

Database Correlations

PUBCHEM cid=173924

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Prescriber's Letter 15(5): 2008 The New Auralgan Formulation Detail-Document#: 240502 (subscription needed) http://www.prescribersletter.com