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anti-Vgcc antibody

Etiology: 1) Lambert-Eaton myasthenic syndrome 2) encephalomyelitis 3) cerebellar degeneration 4) peripheral neuropathy 3) associated malignancy -> small cell lung carcinoma Pathology: Neuronal antigen: -> alpha-1 subunit of presynaptic voltage-gated Ca+2 channel

Related

voltage-dependent Ca+2 channel alpha-1D; Ca+2 channel L type alpha-1 polypeptide isoform 2; Cav1.3 (CACNA1D CACNL1A2, CCHL1A2, CACH3, CACN4)

General

paraneoplastic autoantibody

References

  1. Stuve O & Zamvil SS. In: Medical Immunology 10th edition (2001), Section 3, Clinical Immunology. 38. Neurologic diseases.
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009