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anti-tissue transglutaminase IgA autoantibody
Etiology:
- celiac disease
Pathology:
- celiac disease is precipitated by ingestion of the protein gliadin, a component of wheat gluten
- gliadin initiates mucosal damage which involves an immunological process in individuals with a genetic predisposition
- IgA antibodies against gliadin & endomysium, a structure of smooth muscle connective tissue are found in patients with celiac disease
- tissue transglutaminase is the endomysial autoantigen
- gliadin is a preferred substrate for tissue transglutaminase
Laboratory:
- tissue transglutaminase IgA in serum
General
anti-tissue transglutaminase antibody
References
- Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO,
Schuppan D.
Identification of tissue transglutaminase as the autoantigen
of celiac disease.
Nat Med. 1997 Jul;3(7):797-801.
PMID: 9212111
- Dieterich W, Laag E, Schopper H, Volta U, Ferguson A,
Gillett H, Riecken EO, Schuppan D.
Autoantibodies to tissue transglutaminase as predictors of
celiac disease.
Gastroenterology. 1998 Dec;115(6):1317-21
PMID: 9834256
- Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR,
Sarnesto A, Savilahti E, Collin P, Maki M.
Tissue transglutaminase autoantibody enzyme-linked immunosorbent
assay in detecting celiac disease.
Gastroenterology. 1998 Dec;115(6):1322-8.
PMID: 9834257
- Blackwell PJ, Hill PG, Holmes GK.
Autoantibodies to human tissue transglutaminase: superior
predictors of coeliac disease.
Scand J Gastroenterol. 2002 Nov;37(11):1282-5.
PMID: 12465726
- Medical Knowledge Self Assessment Program (MKSAP) 15,
American College of Physicians, Philadelphia 2009
- Tissue Transglutaminase (tTG) Ab, IgA
Laboratory Test Directory ARUP: 50734
- Tissue Transglutaminase (tTG) Ab, IgA
Laboratory Test Directory ARUP: 97709